Fungi@MANCHESTER | Working Together to Beat Fungal Infection

Why?

How many
are affected?

Treating and caring for patients with fungal diseases is becoming an increasing economic burden. Estimated numbers of patients who will need expensive antifungal drugs for some of the life-threatening fungal illnesses are summarised here.

Invasive aspergillosis kills more than 100 000 per year, mortality is >50%
Around 10% of new leukaemic cases will go on to develop invasive aspergillosis (30 000 per year)
54,000 stem cell transplants are carried out annually. 5,400 will get aspergillosis
216 000 COPD patients will need treatment for aspergillosis
Chronic pulmonary aspergillosis causes more than 450 000 deaths per year
Severe asthma kills 100 000 per year, half of which are related to fungal sensitisation

The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of .

Submitted by F@Manc on June 15, 2018

0 comment(s)

Sdu Pré, Beckmann, N., Almeida, M. Cruz, Sibley, G. E. M., Law, D., Brand, A. C., Birch, M., Read, N. D., and Oliver, J. D., “The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of .”, Antimicrob Agents Chemother, 2018.

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in and Is Critical for Pathogenicity.

Submitted by F@Manc on June 15, 2018

0 comment(s)

A. Johns, Scharf, D. H., Gsaller, F., Schmidt, H., Heinekamp, T., Straßburger, M., Oliver, J. D., Birch, M., Beckmann, N., Dobb, K. S., Gilsenan, J., Rash, B., Bignell, E., Brakhage, A. A., and Bromley, M. J., “A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in and Is Critical for Pathogenicity.”, MBio, vol. 8, no. 4, 2017.

The cytochrome b CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus.

Submitted by F@Manc on June 15, 2018

0 comment(s)

M. Misslinger, Gsaller, F., Hortschansky, P., Müller, C., Bracher, F., Bromley, M. J., and Haas, H., “The cytochrome b CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus.”, Metallomics, vol. 9, no. 11, pp. 1655-1665, 2017.

Research.

Manchester Fungal Infection Group, National Aspergillosis Centre, Mycology Reference Centre all carry out research programs.

The Manchester Fungal Infection Group (MFIG) is

National Aspergillosis Centre, Mycology Reference Centre Manchester

The UK National Aspergillosis Centre has been commissioned (2009) by the Department of Health to provide long term

PhD, training workshops, internships, Microfungi.net

Many opportunities for training and learning are available from fungi@MANCHESTER

What.

Who.

Where.

The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of .

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in and Is Critical for Pathogenicity.

The cytochrome b CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus.

Pages

Research.

Manchester Fungal Infection Group, National Aspergillosis Centre, Mycology Reference Centre all carry out research programs.

Medicine.

National Aspergillosis Centre, Mycology Reference Centre Manchester

Teaching.

PhD, training workshops, internships, Microfungi.net