Serious fungal infections in Canada.

TitleSerious fungal infections in Canada.
Publication TypeJournal Article
Year of Publication2017
AuthorsDufresne, SF, Cole, DC, Denning, DW, Sheppard, DC
JournalEur J Clin Microbiol Infect Dis
Date Published2017 Feb 04
ISSN1435-4373
Abstract

There are currently no nationwide epidemiological data on fungal infections in Canada. We estimated the burden of serious fungal diseases using literature review and modeling, as per a methodology previously described by the LIFE program ( http://www.LIFE-worldwide.org ). Among the population of Canada (35.5 million in 2014), it was estimated that approximately 1.8% are affected by a serious fungal infection. Recurrent vulvovaginal candidiasis, severe asthma with fungal sensitization, and allergic bronchopulmonary aspergillosis are the most frequent infections, with population prevalences of 498,688 (1403/100,000), 73,344 (206/100,000), and 61,854 (174/100,000) cases, respectively. Over 3000 invasive fungal infections are estimated to occur annually, with incidences of 2068 cases (5.8/100,000) of invasive candidiasis, 566 cases (1.6/100,000) of invasive aspergillosis, 252 cases (0.71/100,000) of Pneumocystis pneumonia, 99 cases (0.28/100,000) of endemic mycoses, and 63 cases (0.18/100,000) of cryptococcosis. These estimates warrant validation through more formal epidemiological studies in Canada.

DOI10.1007/s10096-017-2922-y
Alternate JournalEur. J. Clin. Microbiol. Infect. Dis.
PubMed ID28161745