Microbial uptake by the respiratory epithelium: outcomes for host and pathogen.

TitleMicrobial uptake by the respiratory epithelium: outcomes for host and pathogen.
Publication TypeJournal Article
Year of Publication2019
AuthorsBertuzzi, M, Hayes, GE, Bignell, EM
JournalFEMS Microbiol Rev
Volume43
Issue2
Pagination145-161
Date Published2019 03 01
ISSN1574-6976
Abstract

Intracellular occupancy of the respiratory epithelium is a useful pathogenic strategy facilitating microbial replication and evasion of professional phagocytes or circulating antimicrobial drugs. A less appreciated but growing body of evidence indicates that the airway epithelium also plays a crucial role in host defence against inhaled pathogens, by promoting ingestion and quelling of microorganisms, processes that become subverted to favour pathogen activities and promote respiratory disease. To achieve a deeper understanding of beneficial and deleterious activities of respiratory epithelia during antimicrobial defence, we have comprehensively surveyed all current knowledge on airway epithelial uptake of bacterial and fungal pathogens. We find that microbial uptake by airway epithelial cells (AECs) is a common feature of respiratory host-microbe interactions whose stepwise execution, and impacts upon the host, vary by pathogen. Amidst the diversity of underlying mechanisms and disease outcomes, we identify four key infection scenarios and use best-characterised host-pathogen interactions as prototypical examples of each. The emergent view is one in which effi-ciency of AEC-mediated pathogen clearance correlates directly with severity of disease outcome, therefore highlighting an important unmet need to broaden our understanding of the antimicrobial properties of respiratory epithelia and associated drivers of pathogen entry and intracellular fate.

DOI10.1093/femsre/fuy045
Alternate JournalFEMS Microbiol. Rev.
PubMed ID30657899
PubMed Central IDPMC6435450
Grant ListG0501164 / / Medical Research Council / United Kingdom
MR/L000822/1 / / Medical Research Council / United Kingdom
MR/M02010X/1 / / Medical Research Council / United Kingdom
BB/G009619/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
WT093596MA / / Wellcome Trust / United Kingdom
MC-PC_15072 / / Medical Research Council / United Kingdom