Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.

TitleAnti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsBertuzzi, M, Hayes, GE, Icheoku, UJ, van Rhijn, N, Denning, DW, Osherov, N, Bignell, EM
JournalJ Fungi (Basel)
Volume4
Issue1
Date Published2018 Jan 08
ISSN2309-608X
Abstract

Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose a continual antigenic, and potentially pathogenic, challenge to lung integrity against which the human respiratory mucosa has developed various tolerance and defence strategies. However, respiratory disease and immune dysfunction frequently render the human lung susceptible to fungal diseases, the most common of which are the aspergilloses, a group of syndromes caused by inhaled spores of . Inhaled spores enter into a multiplicity of interactions with respiratory epithelia, the mechanistic bases of which are only just becoming recognized as important drivers of disease, as well as possible therapeutic targets. In this mini-review we examine current understanding of -epithelial interactions and, based upon the very latest developments in the field, we explore two apparently opposing schools of thought which view epithelial uptake of spores as either a curative or disease-exacerbating event.

DOI10.3390/jof4010008
Alternate JournalJ Fungi (Basel)
PubMed ID29371501
PubMed Central IDPMC5872311
Grant ListBB/G009619/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
G0501164 / / Medical Research Council / United Kingdom
MR/L000822/1 / / Medical Research Council / United Kingdom
MR/M02010X/1 / / Medical Research Council / United Kingdom